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KMID : 1039420170510050449
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Journal of Pathology and Translational Medicine
2017 Volume.51 No. 5 p.449 ~ p.455
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White Matter Injury of Prematurity: Its Mechanisms and Clinical Features
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Lee Young-Ah
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Abstract
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A developing central nervous system is vulnerable to various insults such as infection and ischemia. While increased understanding of the dynamic nature of brain development allows a deeper insight into the pathophysiology of perinatal brain injury, the precise nature of specific fetal and neonatal brain injuries and their short- and long-term clinical consequences need special attention and further elucidation. The current review will describe the pathophysiological aspects and clinical significance of white matter injury of prematurity, a main form of perinatal brain injury in premature newborns, with a particular emphasis on its potential antenatal components.
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KEYWORD
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Prematurity, Injury, White matter, Periventricular leukomalacia
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